hliu092 发表于 2021-1-4 15:34:49

Gene Mutation, Pathogenesis and Gene Modification/基因突变、致病性机理与基因修改

This is the article 9 in the theme 'Environmental Physiology/环境生理学' of Journal of Environment and Health Science.

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hliu092 发表于 2021-4-5 11:44:09

Article 9. Gene Mutation, Pathogenesis and Gene Modification/
基因突变、致病性机理与基因修改

Author: Liu Huan, MSc (First Class Honours), The University of Auckland

1. Gene Mutation and Its Pathogenesis (1)/基因突变及其致病性机理
Step 1. The host cells with apparent antibiotics of the same genetic strains are identified during the invasive simulation of a specific bacteria strain (Sample 1);

Step 2. The same bacteria strain is cultivated during radiation, leading to gene mutation (Sample-M) detected by FISH using transmission electron microscopy, as described by other articles of this journal;

Step 3. Invasive simulation by Sample-M targeting the host cells with apparent antibiotics, identified in step 1, is conducted.

Step 4. The disease infection by Sample-M is observed.

Step 5. The cell division rate (quantify of cells / cultivation time) is observed and compared between cells with gene mutation and cells without gene mutation.

Hypothesis:

The bacteria with gene mutation leads to altered bio-signal which can be difficultly perceived by host cells with specific immunology against their parental bacteria (sample 1), and the infection rate by sample-M is higher than sample 1.

Discussion:
Gene mutation, leads to cells with faster cell division rate (DNA or RNA replication rate in virus) than their parental cells (or virus). This explains the sharply epidemic infection caused by bacteria or virus with gene mutation (such as AIV).


2. Gene Mutation and Its Pathogenesis (2)/基因突变及其致病性机理
As discussed in chapter 1, gene mutation virus leads to ‘altered’ or distortive bio-signal, which is hardly identified by host cells. Consequently, this chapter presents a novel method to train the host cells’ ‘memory’ in terms of identifying the invasive virus family with gene mutation.

Step 1. The virus classification on the basis of FISH technology is conducted, whichis the morphological markers of genome, as described by other article of this journal.

Step 2. The similar virus families (mild sample) to the pathogenetic virus family with gene mutation (pathogenetic sample) is identified in step 1 on the basis of morphological markers of genome; And the similar virus is less pathogenetic virus (such as becoming dormant in host cells after puncture), which is consequently called as ‘mild’ samples;

Step 3. The specific zymograms of host cells with specific immunology against invasive gene mutation virus is identified, as described above;

Step 4. The biophysical ‘training’ of host cells, described in other article of this journal, is conducted with indication of zymograms in step 3, during the invasive simulation of ‘mild’ samples;

Step 5. This method strengthens the immunology against this gene mutation virus family through similarity invasion simulation.

Discussion:

The pathogenicity of virus invasion in this book is explained by two process: one is to puncture the host cell membrane, and the other is the virus metabolism in host cells after puncture. Consequently, host cells identify the bio-signal of invasive virus by two stages correspondingly: the first stage is the puncture process, and the morphological bio-signal of invasive virus genome is the main bio-signal (this bio-signal by gene mutation virus is similar to the other virus families, rather than its parental virus family); the second stage is the pathogenic metabolism of invasive virus after puncture, and the main bio-signal depends on the gene expression of virus genome (this bio-signal by gene mutation virus is similar to their parental virus). This two process further explains the altered or distortive bio-signal by gene mutation virus.

Please note:
If the specific zymograms of host cells with specific immunology against invasive

gene mutation virus is NOT identified by the method described above; then the specific zymograms of host cells with specific immunology against invasive gene mutation virus has to be identified by adjusting the biophysical parameters during invasion simulation of gene mutation virus in lab, as described in other article of this journal. However, it is expected that the specific zymograms of host cells with specific immunology against invasive gene mutation virus is closer to the specific immunology against their parental virus.

However, for the invasive virus (or bacteria) with dormant characters, it is further discussed in other article of this journal.

3. Gene modification of microbial vaccine/微生物疫苗的基因修改技术
As discussed in other article of this journal, moderate gene mutation is caused by biophysical simulation, which consequently points out a way of cultivation of microbial vaccine. For the pathogenic bacteria or virus, suitable/accurate gene mutation reduces the pathogenicity of these pathogens against host cells, but keeps both metabolic and ecological traits which are similar to their parental and pathogenic bacteria or virus. The new strains engineered by this gene modification provides better way of microbial vaccine production than trans-gene microbes.

Please note: the advantages of inoculation of microbial vaccine is not just to cultivate the host cell’s memory in terms of immunology against their parental and pathogenic microbes, but also for the microbial vaccine to be dominant in host environment by competing with their parental and pathogenic microbes’ invasion, because the microbial vaccine compete for the same ‘ecological niche’ with their parental and pathogenic microbes in host cell environment and shows symbiosis with host cells before their parental and pathogenic microbes invade. For example, if the vaccine microbe already ‘occupies’ a host cell with symbiosis, the metabolic substances of symbiotic vaccine microbe, as a kind of bio-signals, eliminates the re-invasion bytheir parental and pathogenic microbes. This is a common nature of host-invasion interactions. Secondly, the microbial vaccine engineered and created by gene mutation leads to higher cell mutation rate than its parental pathogens so that eliminates the reproduction of parental pathogens which is identified as more pathogenesis against host cell. Consequently, the metabolites of symbiotic vaccine microbe itself are just a kind of effective antibiotics against similar genetic strains, and this competition- exclusion rhythm between different strains of microbes also partly explains that the symbiosis of rhizobium in Leguminosae species leads to antibiotics for biomedicine discussed in other article of this journal.

In this case, the host cells inoculated by symbiotic microbial vaccine can be utilized for exchange transfusion as remediation method, and the symbiosis would not need persist long-termly after cure, because the symbiosis of microbial vaccine may negatively influence the health due to competition for nutrition as well after cure.

Conclusion
Gene mutation is the natural adaptive process of cell evolution in response to environment changes. Moderate gene mutation can be utilized as gene engineering instead of clone Tech due to more nature!












This is the revised materials in book “Proceedings for Degree of Postgraduate
Diploma in Environmental Science (3rd Edition).” Published in 2016.
Secondly revised on 04/01/2021; Thirdly revised on 05/04/2021.

References:


All the science terms in English of this journal source from Wikipedia:
https://encyclopedia.thefreedictionary.com/;
本文所有中文科学专业术语引用自百度百科 https://baike.baidu.com/。

hliu092 发表于 2021-1-4 15:35:11

Article 9. Gene Mutation, Pathogenesis and Gene Modification/基因突变、致病性机理与基因修改

Author: Liu Huan, MSc (First Class Honours), The University of Auckland Published after graduation on data 26/08/2015

1. Gene Mutation and Its Pathogenesis (1)/基因突变及其致病性机理
Step 1. The cells with apparent antibiotics of the same genetic strains are identified during the invasive simulation of a specific bacteria strain (Sample 1);

Step 2. The same bacteria strain is cultivated during radiation, leading to gene mutation (Sample-M) detected by FISH using transmission electron microscopy, as described by other articles of this journal;

Step 3. Invasive simulation by Sample-M targeting the cells with apparent antibiotics, identified in step 1, is conducted.

Step 4. The disease infection by Sample-M is observed.

Step 5. The cell division rate (quantify of cells / cultivation time) is observed and compared between cells with gene mutation and cells without gene mutation.

Hypothesis:

The bacteria with gene mutation leads to altered bio-signal which can be difficultly perceived by cells with specific immunology against their parental bacteria (sample 1), and the infection rate by sample-M is higher than sample 1.

Discussion:
Gene mutation, leads to cells with faster cell division rate (DNA or RNA replication rate in virus) than their parental cells (or virus). This explains the sharply epidemic infection caused by bacteria or virus with gene mutation (such as AIV).


2. Gene Mutation and Its Pathogenesis (1)/基因突变及其致病性机理
As discussed in chapter 1, gene mutation virus leads to ‘altered’ or distortive bio-signal, which is hardly identified by host cells. Consequently, this chapter presents a novel method to train the host cells’ ‘memory’ in terms of identifying the invasive virus family with gene mutation.

Step 1. The virus classification on the basis of FISH technology is conducted, whichis the morphological markers of genome, as described by other article of this journal.

Step 2. The similar virus families (mild sample) to the pathogenetic virus family with gene mutation (pathogenetic sample) is identified in step 1 on the basis of morphological markers of genome; And the similar virus is less pathogenetic virus (such as becoming dormant in host cells after puncture), which is consequently called as ‘mild’ samples;

Step 3. The specific zymograms of host cells with specific immunology against invasive gene mutation virus is identified, as described above;

Step 4. The biophysical ‘training’ of host cells, described in other article of this journal, is conducted with indication of zymograms in step 3, during the invasive simulation of ‘mild’ samples;

Step 5. This method strengthens the immunology against this gene mutation virus family through similarity invasion simulation.

Discussion:

The pathogenicity of virus invasion in this book is explained by two process: one is to puncture the host cell membrane, and the other is the virus metabolism in host cells after puncture. Consequently, host cells identify the bio-signal of invasive virus by two stages correspondingly: the first stage is the puncture process, and the morphological bio-signal of invasive virus genome is the main bio-signal (this bio-signal by gene mutation virus is similar to the other virus families, rather than its parental virus family); the second stage is the pathogenic metabolism of invasive virus after puncture, and the main bio-signal depends on the gene expression of virus genome (this bio-signal by gene mutation virus is similar to their parental virus). This two process further explains the altered or distortive bio-signal by gene mutation virus.

Please note:
If the specific zymograms of host cells with specific immunology against invasive

gene mutation virus is NOT identified by the method described above; thenthe specific zymograms of host cells with specific immunology against invasive gene mutation virus has to be identified by adjusting the biophysical parameters during invasion simulation of gene mutation virus in lab, as described in other article of this journal. However, it is expected that the specific zymograms of host cells with specific immunology against invasive gene mutation virus is closer to the specific immunology against their parental virus.

However, for the invasive virus (or bacteria) with dormant characters, it is further discussed in other article of this journal.

3. Gene modification of microbial vaccine/微生物疫苗的基因修改技术
As discussed in other article of this journal, moderate gene mutation is caused by biophysical simulation, which consequently points out a way of cultivation of microbial vaccine. For the pathogenic bacteria or virus, suitable gene mutation reduces the pathogenicity of these pathogens against host cells, but keeps both metabolic and ecological traits which are similar to their parental and pathogenic bacteria or virus. The new strains engineered by this gene modification provides better way of microbial vaccine production than trans-gene microbes.

Please note: the advantages of inoculation of microbial vaccine is not just to cultivate the host cell’s memory in terms of immunology against their parental and pathogenic microbes, but also for the microbial vaccine to be dominant in host environment by competing with their parental and pathogenic microbes’ invasion, because the microbial vaccine compete for the same ‘ecological niche’ with their parental and pathogenic microbes in host cell environment and shows symbiosis with host cells before their parental and pathogenic microbes invade. For example, if the vaccine microbe already ‘occupies’ a host cell with symbiosis, the metabolic substances of symbiotic vaccine microbe, as a kind of bio-signals, eliminates the re-invasion bytheir parental and pathogenic microbes. This is a common nature of host-invasion interactions. Consequently, the metabolites of symbiotic vaccine microbe itself arejust a kind of effective antibiotics against similar genetic strains, and this competition- exclusion rhythm between different strains of microbes also partly explains that the symbiosis of rhizobium in Leguminosae species leads to antibiotics for biomedicine discussed in other article of this journal.

In this case, the host cells inoculated by symbiotic microbial vaccine can be utilized for exchange transfusion as remediation method, and the symbiosis would not need persist long-termly after cure, because the symbiosis of microbial vaccine may negatively influence the health due to competition for nutrition as well after cure.


Conclusion
Gene mutation is the natural adaptive process of cell evolution in response to environment changes. Moderate gene mutation can be utilized as gene engineering instead of clone Tech due to more nature!












This is the revised materials in book “Proceedings for Degree of Postgraduate
Diploma in Environmental Science (3rd Edition).” published in 2016.
Revised on 04/01/2021.

References:
All the science terms in English of this journal source from Wikipedia:
https://encyclopedia.thefreedictionary.com/;
本文所有中文科学专业术语引用自百度百科 https://baike.baidu.com/。

hliu092 发表于 2021-1-5 09:39:25

Article 9. Gene Mutation, Pathogenesis and Gene Modification/
基因突变、致病性机理与基因修改

Author: Liu Huan, MSc (First Class Honours), The University of Auckland Published after graduation on data 26/08/2015

1. Gene Mutation and Its Pathogenesis (1)/基因突变及其致病性机理
Step 1. The cells with apparent antibiotics of the same genetic strains are identified during the invasive simulation of a specific bacteria strain (Sample 1);

Step 2. The same bacteria strain is cultivated during radiation, leading to gene mutation (Sample-M) detected by FISH using transmission electron microscopy, as described by other articles of this journal;

Step 3. Invasive simulation by Sample-M targeting the cells with apparent antibiotics, identified in step 1, is conducted.

Step 4. The disease infection by Sample-M is observed.

Step 5. The cell division rate (quantify of cells / cultivation time) is observed and compared between cells with gene mutation and cells without gene mutation.

Hypothesis:

The bacteria with gene mutation leads to altered bio-signal which can be difficultly perceived by cells with specific immunology against their parental bacteria (sample 1), and the infection rate by sample-M is higher than sample 1.

Discussion:
Gene mutation, leads to cells with faster cell division rate (DNA or RNA replication rate in virus) than their parental cells (or virus). This explains the sharply epidemic infection caused by bacteria or virus with gene mutation (such as AIV).


2. Gene Mutation and Its Pathogenesis (2)/基因突变及其致病性机理
As discussed in chapter 1, gene mutation virus leads to ‘altered’ or distortive bio-signal, which is hardly identified by host cells. Consequently, this chapter presents a novel method to train the host cells’ ‘memory’ in terms of identifying the invasive virus family with gene mutation.

Step 1. The virus classification on the basis of FISH technology is conducted, whichis the morphological markers of genome, as described by other article of this journal.

Step 2. The similar virus families (mild sample) to the pathogenetic virus family with gene mutation (pathogenetic sample) is identified in step 1 on the basis of morphological markers of genome; And the similar virus is less pathogenetic virus (such as becoming dormant in host cells after puncture), which is consequently called as ‘mild’ samples;

Step 3. The specific zymograms of host cells with specific immunology against invasive gene mutation virus is identified, as described above;

Step 4. The biophysical ‘training’ of host cells, described in other article of this journal, is conducted with indication of zymograms in step 3, during the invasive simulation of ‘mild’ samples;

Step 5. This method strengthens the immunology against this gene mutation virus family through similarity invasion simulation.

Discussion:

The pathogenicity of virus invasion in this book is explained by two process: one is to puncture the host cell membrane, and the other is the virus metabolism in host cells after puncture. Consequently, host cells identify the bio-signal of invasive virus by two stages correspondingly: the first stage is the puncture process, and the morphological bio-signal of invasive virus genome is the main bio-signal (this bio-signal by gene mutation virus is similar to the other virus families, rather than its parental virus family); the second stage is the pathogenic metabolism of invasive virus after puncture, and the main bio-signal depends on the gene expression of virus genome (this bio-signal by gene mutation virus is similar to their parental virus). This two process further explains the altered or distortive bio-signal by gene mutation virus.

Please note:
If the specific zymograms of host cells with specific immunology against invasive

gene mutation virus is NOT identified by the method described above; then the specific zymograms of host cells with specific immunology against invasive gene mutation virus has to be identified by adjusting the biophysical parameters during invasion simulation of gene mutation virus in lab, as described in other article of this journal. However, it is expected that the specific zymograms of host cells with specific immunology against invasive gene mutation virus is closer to the specific immunology against their parental virus.

However, for the invasive virus (or bacteria) with dormant characters, it is further discussed in other article of this journal.

3. Gene modification of microbial vaccine/微生物疫苗的基因修改技术
As discussed in other article of this journal, moderate gene mutation is caused by biophysical simulation, which consequently points out a way of cultivation of microbial vaccine. For the pathogenic bacteria or virus, suitable gene mutation reduces the pathogenicity of these pathogens against host cells, but keeps both metabolic and ecological traits which are similar to their parental and pathogenic bacteria or virus. The new strains engineered by this gene modification provides better way of microbial vaccine production than trans-gene microbes.

Please note: the advantages of inoculation of microbial vaccine is not just to cultivate the host cell’s memory in terms of immunology against their parental and pathogenic microbes, but also for the microbial vaccine to be dominant in host environment by competing with their parental and pathogenic microbes’ invasion, because the microbial vaccine compete for the same ‘ecological niche’ with their parental and pathogenic microbes in host cell environment and shows symbiosis with host cells before their parental and pathogenic microbes invade. For example, if the vaccine microbe already ‘occupies’ a host cell with symbiosis, the metabolic substances of symbiotic vaccine microbe, as a kind of bio-signals, eliminates the re-invasion bytheir parental and pathogenic microbes. This is a common nature of host-invasion interactions. Consequently, the metabolites of symbiotic vaccine microbe itself arejust a kind of effective antibiotics against similar genetic strains, and this competition- exclusion rhythm between different strains of microbes also partly explains that the symbiosis of rhizobium in Leguminosae species leads to antibiotics for biomedicine discussed in other article of this journal.

In this case, the host cells inoculated by symbiotic microbial vaccine can be utilized for exchange transfusion as remediation method, and the symbiosis would not need persist long-termly after cure, because the symbiosis of microbial vaccine may negatively influence the health due to competition for nutrition as well after cure.


Conclusion
Gene mutation is the natural adaptive process of cell evolution in response to environment changes. Moderate gene mutation can be utilized as gene engineering instead of clone Tech due to more nature!












This is the revised materials in book “Proceedings for Degree of Postgraduate
Diploma in Environmental Science (3rd Edition).” published in 2016.
Revised on 04/01/2021.

References:
All the science terms in English of this journal source from Wikipedia:
https://encyclopedia.thefreedictionary.com/;
本文所有中文科学专业术语引用自百度百科 https://baike.baidu.com/。

hliu092 发表于 2021-1-6 10:24:49

Article 9. Gene Mutation, Pathogenesis and Gene Modification/基因突变、致病性机理与基因修改

Author: Liu Huan, MSc (First Class Honours), The University of Auckland Published after graduation on data 26/08/2015

1. Gene Mutation and Its Pathogenesis (1)/基因突变及其致病性机理
Step 1. The cells with apparent antibiotics of the same genetic strains are identified during the invasive simulation of a specific bacteria strain (Sample 1);

Step 2. The same bacteria strain is cultivated during radiation, leading to gene mutation (Sample-M) detected by FISH using transmission electron microscopy, as described by other articles of this journal;

Step 3. Invasive simulation by Sample-M targeting the cells with apparent antibiotics, identified in step 1, is conducted.

Step 4. The disease infection by Sample-M is observed.

Step 5. The cell division rate (quantify of cells / cultivation time) is observed and compared between cells with gene mutation and cells without gene mutation.

Hypothesis:

The bacteria with gene mutation leads to altered bio-signal which can be difficultly perceived by cells with specific immunology against their parental bacteria (sample 1), and the infection rate by sample-M is higher than sample 1.

Discussion:
Gene mutation, leads to cells with faster cell division rate (DNA or RNA replication rate in virus) than their parental cells (or virus). This explains the sharply epidemic infection caused by bacteria or virus with gene mutation (such as AIV).


2. Gene Mutation and Its Pathogenesis (2)/基因突变及其致病性机理
As discussed in chapter 1, gene mutation virus leads to ‘altered’ or distortive bio-signal, which is hardly identified by host cells. Consequently, this chapter presents a novel method to train the host cells’ ‘memory’ in terms of identifying the invasive virus family with gene mutation.

Step 1. The virus classification on the basis of FISH technology is conducted, whichis the morphological markers of genome, as described by other article of this journal.

Step 2. The similar virus families (mild sample) to the pathogenetic virus family with gene mutation (pathogenetic sample) is identified in step 1 on the basis of morphological markers of genome; And the similar virus is less pathogenetic virus (such as becoming dormant in host cells after puncture), which is consequently called as ‘mild’ samples;

Step 3. The specific zymograms of host cells with specific immunology against invasive gene mutation virus is identified, as described above;

Step 4. The biophysical ‘training’ of host cells, described in other article of this journal, is conducted with indication of zymograms in step 3, during the invasive simulation of ‘mild’ samples;

Step 5. This method strengthens the immunology against this gene mutation virus family through similarity invasion simulation.

Discussion:

The pathogenicity of virus invasion in this book is explained by two process: one is to puncture the host cell membrane, and the other is the virus metabolism in host cells after puncture. Consequently, host cells identify the bio-signal of invasive virus by two stages correspondingly: the first stage is the puncture process, and the morphological bio-signal of invasive virus genome is the main bio-signal (this bio-signal by gene mutation virus is similar to the other virus families, rather than its parental virus family); the second stage is the pathogenic metabolism of invasive virus after puncture, and the main bio-signal depends on the gene expression of virus genome (this bio-signal by gene mutation virus is similar to their parental virus). This two process further explains the altered or distortive bio-signal by gene mutation virus.

Please note:
If the specific zymograms of host cells with specific immunology against invasive gene mutation virus is NOT identified by the method described above; then the specific zymograms of host cells with specific immunology against invasive gene mutation virus has to be identified by adjusting the biophysical parameters during invasion simulation of gene mutation virus in lab, as described in other article of this journal. However, it is expected that the specific zymograms of host cells with specific immunology against invasive gene mutation virus is closer to the specific immunology against their parental virus.

However, for the invasive virus (or bacteria) with dormant characters, it is further discussed in other article of this journal.

3. Gene modification of microbial vaccine/微生物疫苗的基因修改技术
As discussed in other article of this journal, moderate gene mutation is caused by biophysical simulation, which consequently points out a way of cultivation of microbial vaccine. For the pathogenic bacteria or virus, suitable gene mutation reduces the pathogenicity of these pathogens against host cells, but keeps both metabolic and ecological traits which are similar to their parental and pathogenic bacteria or virus. The new strains engineered by this gene modification provides better way of microbial vaccine production than trans-gene microbes.

Please note: the advantages of inoculation of microbial vaccine is not just to cultivate the host cell’s memory in terms of immunology against their parental and pathogenic microbes, but also for the microbial vaccine to be dominant in host environment by competing with their parental and pathogenic microbes’ invasion, because the microbial vaccine compete for the same ‘ecological niche’ with their parental and pathogenic microbes in host cell environment and shows symbiosis with host cells before their parental and pathogenic microbes invade. For example, if the vaccine microbe already ‘occupies’ a host cell with symbiosis, the metabolic substances of symbiotic vaccine microbe, as a kind of bio-signals, eliminates the re-invasion bytheir parental and pathogenic microbes. This is a common nature of host-invasion interactions. Consequently, the metabolites of symbiotic vaccine microbe itself arejust a kind of effective antibiotics against similar genetic strains, and this competition- exclusion rhythm between different strains of microbes also partly explains that the symbiosis of rhizobium in Leguminosae species leads to antibiotics for biomedicine discussed in other article of this journal.

In this case, the host cells inoculated by symbiotic microbial vaccine can be utilized for exchange transfusion as remediation method, and the symbiosis would not need persist long-termly after cure, because the symbiosis of microbial vaccine may negatively influence the health due to competition for nutrition as well after cure.


Conclusion
Gene mutation is the natural adaptive process of cell evolution in response to environment changes. Moderate gene mutation can be utilized as gene engineering instead of clone Tech due to more nature!









This is the revised materials in book “Proceedings for Degree of Postgraduate Diploma in Environmental Science (3rd Edition).” Published in 2016. The ‘chapter’ content mentioned in this article is in previous book. Revised on 05/01/2021.

References:
All the science terms in English of this journal source from Wikipedia:
https://encyclopedia.thefreedictionary.com/;
本文所有中文科学专业术语引用自百度百科 
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