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Updated Viewpoints to COVID-19 epidemiology:

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发表于 2021-1-3 17:08:51 | 显示全部楼层 |阅读模式
Author: Liu Huan, MSc (First Class Honours), The University of Auckland.

Published as Newsletter updated.

The formally published serials is the printing <Journal of Environment and Health Science (ISSN 2314-1628)>, and the serials NO. is the month/year when the materials accessible on this website, authorized by publisher;
正式发表的期刊是印刷版《环境与卫生科学杂志(ISSN 2314-1628)》,期刊期号为文章内容在本网站上网年/月,出版人许可自行正式发表。
References:
All the science terms in English of this journal source from Wikipedia:
https://encyclopedia.thefreedictionary.com/;
本文所有中文科学专业术语引用自百度百科 https://baike.baidu.com/

Originality Certificate: The originality of text in English is 98% tested by Turnitin (International). The Turnitin Originality Report is attached in PDF summary.
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 楼主| 发表于 2021-1-12 10:31:18 | 显示全部楼层
Updated Viewpoints to COVID-19 epidemiology:

Author: Liu Huan, MSc (First Class Honours), The University of Auckland.

A viewpoint to COVID 19 virus on 02/04/2020:
Natural conservation also contributes to the prevention of epidemic virus from breaking out, because there are more diversity in natural microbes which compete with this epidemic virus within the community of the same ecological niche, reducing epidemic events. The mono-strain of microbes increases epidemic risks. From above viewpoint, the broad scope and large scale of epidemic COVID 19 virus, which exceeds the historic epidemic events in the past, reflect that the biodiversity decreases in natural microbe community. Specifically urban biodiversity conservation is mostly closed to the human health.

A viewpoint of population immunology and its application on the COVID 19 outbreak on 27/04/2020:
Firstly, the formation of population immunology should be explored from the establishment of individual immunity. For COVID 19 coronavirus, one of the pre-conditions of individual immunity should be established by the presence of pathogen biodiversity in the host ecosystem. Before the outbreak of the COVID 19 coronavirus, if individuals have been infected by its relatives virus strains, leading to the establishment of immunity, and the sub-populations of relatives coronavirus strains is less pathogenic and epidemic than COVID 19 strains, then the outbreak of the COVID 19 coronavirus can certainly be prevented, as population immunology would be formed before. However, the outbreak of COVID 19 coronavirus is very sudden, showing the invasive strain status in the receptor’s living ecosystem without any biodiversity in virus community.

Then, the pathogenesis of COVID 19 coronavirus is analyzed by the specificity of invasion-host interactions. In almost cases, epidemic disease only infects a proportion of host population, and the other proportion is resistance against the pathogens due to the specificity of invasion-host interaction between population genetics. However, the non-selective infections of COVID 19 coronavirus reveals the deletion of specificity of invasion – host interactions between population genetics, further indicating that the previous host species of COVID 19 coronavirus has apparent genetic distance to the human population, so that the valid biochemical substances of immunity is the enzymes synthesized by the allogenetic chromosomes of a wild animal species as compared with human genomes. Consequently, the inoculation of allogenetic enzymes would not be promising. The absences in the above two pre-conditions reveals that the population immunology formation of COVID 19 coronavirus would not be realistic, so that the isolation remedy of infection receptors is the only reliable measure to resolve the outbreak of COVID 19 coronavirus.   

A viewpoint on 21/12/2020
The Metabolomics and Its Application on the Medicine Production/新陈代谢组学在新药生产中的应用

最近看了一些关于新药的新闻报道的特征描述,提出以下学术观点:本文在之前学术论文《新陈代谢组学》中一直提出使用同工酶最为指示性生化指标对病理进行分析才保证其长期稳定、可靠的表现型特征,不容易受制于环境条件的影响。如果是选用mRNA或是tRNA作为指示性生化分子,在此基础上对最终表现出来的抗体是否呈现阳性进行相关性分析,不会有长期稳定的正相关特性,而且容易受制于环境条件的影响(比如测试前期的饮食、生理作息时间等也可能会对mRNA测试结果产生显著影响)。这对于疫苗抗体的有效性分析尤其重要。因此这类疫苗抗体仅仅类似于西药,产生短期治疗效果。

Recently, I have read the biochemical characteristics of some News reports about new drugs, and presented the following academic viewpoints: in the previous academic paper of metabolomics, it is proposed that the selection of isozymes as the indicative biochemical molecules for pathological analysis mostly relates its phenotype characteristics, which is stable and less environmental sensitive in the long-term. If medicines research chooses mRNA or tRNA as biochemical indicator, it is not expected to show a long-term stable and positive correlation to the eventual phenotype of antibody against virus, and is susceptible to environmental conditions (such as diet and physiological work-rest timetable may significantly influence the results of bio-tests on mRNA) , and this is especially for the analysis of immunology generated by vaccine inoculation. The vaccine produced on the basis of the later indicator is similar to biochemical medicines only, which plays the role in remedy in the short term.

A viewpoint on 03/01/2021
In this article, it is further to proposed that compared with the DNA sequences technology utilization only, the combination of both FISH technology and DNA sequences technology in this article results in different classification conclusions due to the relativity nature of statistics in Multivariate Classification Analysis, which is more reasonable for virus testing in terms of reflecting the whole DNA/genome information. This article further concludes that the fragment information of DNA sequences does not indicates the total pathological characters of virus, because the gene mutation does not only lead to the alteration of DNA sequences in a specific fragment, but also results in the significant changes in genome morphology which plays the key role in virus invasion process. Consequently, the virus testing based on the fragment DNA sequences only is not a reliable method to reveal the total gene mutation characters. This is especially important for COVID 19 testing.
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 楼主| 发表于 2021-1-3 17:09:33 | 显示全部楼层
Updated Viewpoints to COVID-19 epidemiology:


Author: Liu Huan, MSc (First Class Honours), The University of Auckland.
A viewpoint to COVID 19 virus on 02/04/2020:
Natural conservation also contributes to the prevention of epidemic virus from breaking out, because there are more diversity in natural microbes which compete with this epidemic virus within the community of the same ecological niche, reducing epidemic events. The mono-strain of microbes increases epidemic risks. From above viewpoint, the broad scope and large scale of epidemic COVID 19 virus, which exceeds the historic epidemic events in the past, reflect that the biodiversity decreases in natural microbe community. Specifically urban biodiversity conservation is mostly closed to the human health.


A viewpoint of population immunology and its application on the COVID 19 outbreak on 27/04/2020:
Firstly, the formation of population immonology should be explored from the establishment of individual immunity. For COVID 19 coronavirus, one of the pre-conditions of individual immunity should be established by the presence of pathogen biodiversity in the host ecosystem. Before the outbreak of the COVID 19 coronavirus, if individuals have been infected by its relatives virus strains, leading to the establishment of immunity, and the sub-populations of relatives coronavirus strains is less pathogenic and epidemic than COVID 19 strains, then the outbreak of the COVID 19 coronavirus can certainly be prevented, as population immunology would be formed before. However, the outbreak of COVID 19 coronavirus is very sudden, showing the invasive strain status in the receptor’s living ecosystem without any biodisersity in virus community.

Then, the pathogenisis of COVID 19 coronavirus is analyzed by the specificity of invasion-host interactions. In almost cases, epidemic disease only infects a proportion of host population, and the other proportion is resistance against the pathogens due to the specificity of invasion-host interaction between population genetics. However, the non-selective infections of COVID 19 coronavirus reveals the deletion of specificity of invation – host interactions between population genetics, further indicating that the previous host species of COVID 19 coronavirus has apparent genetic distance to the human population, so that the valid biochemical substances of immunity is the enzymes synthesized by the allogenetic chromosomes of a wild animal species as compased with human genomes. Consequently, the inoculation of allogenetic enzymes would not be promising. The absences in the above two pre-conditions reveals that the population immunology formation of COVID 19 coronavirus would not be realistic, so that the isolation remedy of infection receptors is the only reliable measure to resolve the outbreak of COVID 19 coronavirus.   

A viewpoint on 21/12/2020
The Metabolomics and Its Application on the Medicine Production/新陈代谢组学在新药生产中的应用

最近看了一些关于新药的新闻报道的特征描述,提出以下学术观点:本文在之前学术论文《新陈代谢组学》中一直提出使用同工酶最为指示性生化指标对病理进行分析才保证其长期稳定、可靠的表现型特征,不容易受制于环境条件的影响。如果是选用mRNA或是tRNA作为指示性生化分子,在此基础上对最终表现出来的抗体是否呈现阳性进行相关性分析,不会有长期稳定的正相关特性,而且容易受制于环境条件的影响(比如测试前期的饮食、生理作息时间等也可能会对mRNA测试结果产生显著影响)。这对于疫苗抗体的有效性分析尤其重要。因此这类疫苗抗体仅仅类似于西药,产生短期治疗效果。

Recently, I have read the biochemical characteristics of some News reports about new drugs, and presented the following academic viewpoints: in the previous academic paper of metabolomics, it is proposed that the selection of isozymes as the indicative biochemical molecules for pathological analysis mostly relates its phenotype characteristics, which is stable and less environmental sensitive in the long-term. If medicines research chooses mRNA or tRNA as biochemical indicator, it is not expected to show a long-term stable and positive correlation to the eventual phenotype of antibody against virus, and is suscitible to environmental conditions (such as diet and physiological work-rest timetable may significantly influence the results of bio-tests on mRNA) , and this is especially for the analysis of immunology generated by vaccine inoculation. The vaccine produced on the basis of the later indicator is similar to biochemical medicines only, which plays the role in remedy in the short term.

A viewpoint on 03/01/2021
In this article, it is further to proposed that compared with the DNA sequences technology utilization only, the combination of both FISH technology and DNA sequences technology in this article results in different classification conclusions due to the relativity nature of statistics in Multivariate Classification Analysis, which is more reasonable for virus testing in terms of reflecting the whole DNA/genome information. This article further concludes that the fragment information of DNA sequences does not indicates the total pathological characters of virus, because the gene mutation does not only lead to the alteration of DNA sequences in a specific fragment, but also results in the significant changes in genome morphology which plays the key role in virus invasion process. Consequently, the virus testing based on the fragment DNA sequences only is not a reliable method to reveal the total gene mutation characters. This is especially important for COVID 19 testing.     
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